HIV-1 transcriptional latency in resting CD4 T-cell
نویسندگان
چکیده
منابع مشابه
CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 3...
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HIV establishes a latent reservoir in a small pool of resting CD4+ T cells early in the infection of a new host. This viral reservoir has a very slow rate of decay and it is resistant to anti-retroviral therapy and the immune surveillance. This reservoir poses a significant obstacle to the eradication of virus in an infected individual. It is thus of importance to understand how this reservoir ...
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Reversal of proviral latency is being pursued as a curative strategy for HIV-1 infection. Recent clinical studies of in vivo administration of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA; vorinostat) show increases in unspliced cellular HIV-1 RNA levels in resting CD4(+) T cells. A critical unknown, however, is the proportion of latent proviruses that can be transcri...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2015
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)31290-5